Is caffeine good for you? – HealthyCell

Introduction

Did you know that approximately 2.25 billion cups of coffee and about 3.7 billion cups of tea are consumed globally each day? 

People drink coffee and tea for a variety of reasons, ranging from physiological effects to cultural and social factors including:

• Caffeine: Both coffee and tea contain caffeine, which acts as a stimulant. Caffeine can help improve alertness, concentration, and energy levels. 
• Caffeine is widely used by students and professionals to enhance focus and productivity. Coffee, tea, and energy drinks are common choices during work or study sessions.
• Waking-up and Focusing: Many people drink coffee or tea to help wake up in the morning or to stay alert during the day.
• In the United States, about 64% of adults drink coffee daily, with many consuming it first thing in the morning.
• The Tea Association of the USA reports that over 159 million Americans drink tea on any given day. In countries like China, India, and the UK, tea consumption is even higher.
• Variety and Convenience: Coffee and tea offer a wide range of flavors and aromas. Coffee can be bold, nutty, fruity, or smoky, while tea can be earthy, floral, sweet, or bitter. Many varieties are widely available and can be easily prepared at home or purchased from a café.
• Tradition: In many cultures, drinking coffee or tea is a longstanding tradition. For example, there are tea ceremonies in Japan, the British schedule afternoon tea, and in Turkey there are many coffee rituals.
• Socializing: Coffee shops and tea houses are popular places for socializing or for conducting business meetings. Meeting for a coffee or tea is a common social activity in many cultures.
• Comfort: The act of drinking a warm beverage can be soothing and provide a sense of comfort and relaxation.

Caffeine’s ubiquity in daily life is evident from its widespread consumption in various forms, like coffee and tea, and its presence in cultural, social, and economic contexts around the world. While caffeine has many benefits, excessive consumption or sensitivity to caffeine can lead to several risks, including insomnia, jitteriness, increased heart rate, digestive issues, mood swings, anxiety, poor calcium absorption, and dependency.

This article will detail the benefits and risks of caffeine as well as how L-theanine can moderate caffeine’s effects. 

Understanding Caffeine

Caffeine is a bitter substance that is naturally found in more than sixty plants including coffee beans, tea leaves, yerba mate, kola nuts (used to flavor soft drinks), cacao pods (used to make chocolate), and guarana berries.

There is also synthetic (man-made) caffeine, which is added to medicines, foods, and drinks. For example, some pain relievers, cold medicines, and over-the-counter medicines for alertness contain synthetic caffeine. Many popular energy drinks and “energy-boosting” gums and snacks will also contain synthetic and artificial caffeine. 

Benefits of Caffeine

Caffeine offers several potential benefits, particularly when consumed in moderation. Here are some of the key advantages associated with caffeine consumption:

• Enhanced Alertness and Concentration: Caffeine is a central nervous system stimulant, which means it increases activity in your brain and nervous system. It temporarily wards off drowsiness and restores alertness. It works primarily by blocking the action of adenosine, a neurotransmitter that promotes sleep, by binding to its receptors, thereby inactivating them (1).
• Improved Cognitive Performance and Memory: Studies show that caffeine plays a role in enhancing processing speed, making it easier to perform tasks that require attention. The majority of the studies reviewed suggest that caffeine has a significant positive effect on both short and long-term memory in adults and the elderly (2).
• Protection Against Cognitive Decline: Regular caffeine consumption has been associated with a lower risk of neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease (3).
• Enhanced Physical Endurance: Caffeine can improve physical performance by increasing adrenaline levels and breaking down body fat, making energy available for exercise. Current guidelines recommend the ingestion of low-to-moderate doses of caffeine, ranging from 3 to 6 mg/kg, approximately 60 min prior to exercise to get these improvements (4). Higher doses of caffeine (9–13 mg/kg) do not result in an additional improvement in physical performance, which may be linked to the incidence and magnitude of caffeine-related side effects (4). Additionally, it appears that men are able to produce more power, greater total weight lifted and more speed with the same dose of caffeine than women (5).
• Reduced Perceived Effort: Caffeine may also decrease the perception of effort during physical activities, allowing individuals to exercise longer and more intensively (6).
• Mood Enhancement: Caffeine can have acute mood-lifting effects in healthy adults who are commonly plagued by mental and physical fatigue (7) and may reduce the risk of depression by increasing the availability of natural mood enhancing neurotransmitters such as dopamine, serotonin,  norepinephrine, and GABA (1).
• Increased Metabolism: Caffeine can boost metabolic rate and increase fat burning, making it a common ingredient in weight loss supplements (8).
• Pain Relief: Caffeine is a common ingredient in over-the-counter pain relievers and can help enhance their effectiveness, particularly for postoperative dental pain, postpartum pain, headache, and migraine relief (9,10).  

Risks and Drawbacks of Caffeine

While caffeine has many benefits, excessive consumption or sensitivity to caffeine can lead to several downsides. Some of the negative psychomotor risks associated with caffeine are as follows:

• Sleep Disruption and Reduced Sleep Duration: Caffeine can interfere with sleep patterns, making it harder to fall asleep and reducing sleep quality. Consuming caffeine late in the day can lead to shorter sleep duration (11).
• Dependence and Withdrawal Issues: Regular consumption can lead to physical dependence, while stopping abruptly can cause withdrawal symptoms including headaches, fatigue, irritability, and difficulty concentrating, typically lasting a few days to a week. Chronic repetitive exposures to caffeine increase the risks for development of analgesic-overuse headache, chronic daily headache, and physical dependency (12). Relying on caffeine to manage energy levels can mask underlying issues such as feeling like you can’t function without caffeine, or that you aren’t fully awake until you’ve had it, Increased blood pressure, racing heart, or other heartbeat abnormalities, chronic fatigue or poor sleep hygiene.
• Heart-Related Issues: Caffeine can have different effects on the heart depending on the amount consumed and whether the person is a regular coffee drinker. High doses of caffeine can cause palpitations, skipped beats or palpitations in people who are more susceptible to abnormal heart rhythms.  For people who don’t regularly drink coffee, caffeine can increase blood pressure, heart rate, and cardiac index, and activate the sympathetic nervous system (13). Additionally, caffeine can interact with certain medications, including stimulants, some antibiotics, and heart medications, potentially altering their effects.
• Increased Anxiety and Jitters: High doses of caffeine (as in about 5 cups of coffee) can lead to increased anxiety, nervousness, and restlessness. These effects are exacerbated in people with panic disorders  and mental health disorders (14). Excessive caffeine can also lead to mood swings and exacerbate symptoms of certain mental health conditions, such as anxiety disorders (14). Some individuals may also experience tremors or a jittery feeling, particularly if they consume a large amount of caffeine in a short period (15).
• General Overconsumption Risk: Excessive caffeine consumption can cause additional negative health consequences such as gastrointestinal complaints by increasing the production of stomach acid, which can lead to stomach upset, acid reflux, or heartburn, as well as frequent urination that could potentially lead to dehydration if not enough fluids are consumed (13). High caffeine intake during pregnancy is associated with risks such as low birth weight, preterm birth, and miscarriage. Since metabolism of caffeine by pregnant woman is slowed down, caffeine and its metabolites pass freely across the placenta into a fetus. For this reason, pregnant women should limit caffeine intake (16). 

Moderating Caffeine’s Effects with L-Theanine

L-theanine is an amino acid predominantly found in tea leaves, particularly green tea, and to a lesser extent in black tea. While L-theanine is found in all teas, matcha is expected to have a stress-reducing effect due to its high content (17). L-theanine is also present in some mushrooms. 

L-theanine is known for its calming effects and is often used as a dietary supplement to promote relaxation and reduce stress without causing drowsiness (18). When L-theanine is supplemented with magnesium, they improve sleep quality (latency and duration) by boosting slow-brain waves, regulating brain electrical activity, and increasing the neurotransmitter and GABA receptor levels (19). 

Recently, researchers have discovered neuroprotective effects of L-theanine, which can be attributed to its structural analogy with glutamate, the principal excitatory neurotransmitter in brain. By suppressing exocytotic release of glutamate, L-theanine provides a neuroprotective and cognitive enhancing effect associated with improvement in learning and memory (20, 21).

How L-Theanine Moderates Caffeine’s Effects

When combined with caffeine, L-theanine can moderate and enhance the effects of caffeine, leading to a more balanced and desirable experience. Here’s how L-theanine interacts with caffeine:

• Improves Mood and Reduces Stress: L-theanine increases the production of alpha brain waves, which are associated with a relaxed yet alert mental state (18). This can enhance mood and reduce stress, providing a calmer sense of focus (22).
• Reduces Jitters: L-theanine promotes relaxation by increasing the production of gamma-aminobutyric acid (GABA), a neurotransmitter that has calming effects on the brain (21). This can counteract the jittery and anxious feelings that some people experience with caffeine consumption. 
• Improved Focus, Attention, and Memory: Studies have shown that the combination of L-theanine and caffeine can improve cognitive performance more effectively than caffeine alone. This includes improvements in attention, focus, and accuracy (17). L-theanine works to help sustain attention and focus over longer periods, counteracting the potential for a rapid peak and crash in energy levels that caffeine alone might cause. Additionally, the combination of caffeine’s stimulating effects and L-theanine’s calming effects can lead to improved learning and memory. This synergy allows for better cognitive processing and information retention (23).
• Balanced Stimulation: Caffeine can cause a rapid increase in energy followed by a crash. L-theanine helps to smooth out these peaks and valleys, providing a more consistent and sustained energy boost. This balanced stimulation can be particularly beneficial for tasks requiring prolonged mental effort and focus (23). 

Practical Tips for Caffeine Consumption

As outlined above, caffeine can have several benefits, but it can also have negative effects. To maximize the benefits when while minimizing the downside of caffeine, follow these tips:

• Know Your Limit: A typical effective dose of caffeine is between 50-200 mg. The general guideline is up to 400 mg per day for most adults, equivalent to about four 8-ounce cups of brewed coffee. Since individual responses to caffeine vary, pay attention to your body and adjust your intake accordingly. If you are caffeine sensitive, you may need to consume less. Tracking your caffeine intake and its effects on your body, mood, and sleep can help you find your optimal consumption pattern. If you are experiencing jitters, headaches, or digestive issues, you may need to reduce your caffeine intake, but do so gradually to minimize withdrawal symptoms.

• Timing Matters: To minimize sleep interruptions, aim to consume caffeine in the morning to help wake up and boost alertness. Avoid consuming caffeine in the late afternoon or evening to prevent sleep disruption. The mean half-life of caffeine in plasma of healthy individuals is about 5 hours. However, caffeine’s elimination half-life can range between 1.5 and 9.5 hours (3). Depending on your sensitivity, try to have your last dose at least 6 hours and up to 9.5 hours before bedtime.
• Choose Your Sources Wisely: Opt for natural sources like coffee and tea over sugary energy drinks or sodas. These natural sources often provide additional health benefits like antioxidants and polyphenols. If you enjoy the taste of coffee or tea but are sensitive to caffeine, consider decaffeinated options.
• Stay Hydrated: Caffeine can have a diuretic effect, so it’s essential to drink plenty of water throughout the day to stay hydrated.
• Be Mindful of Hidden Sources: Check the labels of sodas, energy drinks, and medications for caffeine content to avoid unintentional overconsumption. Be mindful that some foods, like chocolate, also contain caffeine.
• Healthy Accompaniments: Avoid adding sugar or high-calorie creamers to your coffee or tea. Choose healthier alternatives like milk or unsweetened almond milk. Pair your caffeinated beverages with healthy foods versus sugary sweet breads, cakes, cookies, pastry, or candy to avoid energy crashes caused by fluctuating blood sugar levels.
• Use Caffeine Strategically: Consuming caffeine about 30-60 minutes before a workout can enhance physical performance and endurance.  Caffeine can also be used strategically for tasks that require intense concentration, such as studying or detailed work.
• Manage Consumption: If you are looking to cut back on caffeine, consider caffeine-free herbal teas, chicory coffee, or simply hot water with lemon. Boost your energy levels naturally through positive lifestyle habits including optimizing sleep, staying hydrated, consuming nutrient dense foods, exercising regularly, managing stress. Spending time outside during the day to get natural sunlight exposure can help regulate your circadian rhythm and boost mood and energy levels. You might also want to take supplements to address deficiencies, such as vitamin D, B vitamins, iron, or magnesium. The HealthyCell Focus & Recall supplement provides nutrients needed for long-term brain health not found in other caffeine beverages or supplements. With a powerful blend of B vitamins, L-theanine, L-tyrosine, Huperzine A, Omega-3, and phosphatidylserine for better brain focus, sharper concentration, and improved cognitive awareness for rapid learning and better recall, Focus & Recall is the perfect alternative to any caffeinated beverage or supplement for both short- and long-term benefits.
• Pair caffeine with L-theanine: Since caffeine provides stimulation and alertness, and L-theanine promotes relaxation without drowsiness, paired together, they can enhance focus, attention, and cognitive performance. The typical ratio for combining with caffeine is 2:1 (L-theanine to caffeine). For example, 100 mg of caffeine with 200 mg of L-theanine. Green Tea naturally contains both caffeine and L-theanine, though in lower doses. This can provide a mild, balanced effect. If you prefer a more precise dosage, consider using caffeine and L-theanine supplements. The HealthyCell Focus & Recall supplement is designed to provide the ideal ratio and expertly formulated to keep you alert, sharp, and focused throughout the day without the negative side effects that you would experience with alternative caffeine sources. Although Focus & Recall does contain 40mg of naturally sourced caffeine, its superior nutrient delivery with MicroGel™ technology provides noticeable benefits within 30 minutes.  

Conclusion

In summary, it is important to note that while moderate caffeine consumption is generally safe for most people, excessive intake or sensitivity to caffeine can lead to various negative health effects. It’s important to monitor caffeine consumption and be aware of how it affects your body, adjusting intake accordingly to avoid any of the potential downsides. By following the practical tips outlined above, you can enjoy the benefits of caffeine while minimizing its potential negative effects. Combining caffeine with L-theanine can provide a balanced, synergistic effect that enhances focus, mood, and cognitive performance while reducing the risk of jitteriness and anxiety. HealthyCell’s Focus & Recall is the easiest one-a-day way to support a healthy brain, focus, and recall with a 40mg dose caffeine. Its combination of natural ingredients, including caffeine and L-theanine, provides a balanced and sustained boost in mental energy and focus, helping to improve overall mental clarity and productivity. By managing your caffeine intake wisely, choosing the right sources, timing your intake correctly, staying hydrated, and listening to your body, you can significantly support brain function, maintain cognitive health, mental performance, improve mood, and maximize overall well-being. 

References 

1. Institute of Medicine (US) Committee on Military Nutrition Research. 2001. Caffeine for the Sustainment of Mental Task Performance: Formulations for Military Operations. (https://www.ncbi.nlm.nih.gov/books/NBK223808/ 07/17/2024)
2. Brian Fiani, Lawrence Zhu, Brian L Musch, Sean Briceno, Ross Andel, Nasreen Sadeq, and Ali Z Ansari. The Neurophysiology of Caffeine as a Central Nervous System Stimulant and the Resultant Effects on Cognitive Function. Cureus. 2021 May; 13(5): e15032.
3. Regina Wierzejska. Can coffee consumption lower the risk of Alzheimer’s disease and Parkinson’s disease? A literature review. Arch Med Sci. 2017 Apr 1; 13(3): 507–514.
4. Simone Cappelletti, Piacentino Daria, Gabriele Sani, and Mariarosaria Aromatario. Caffeine: Cognitive and Physical Performance Enhancer or Psychoactive Drug? Curr Neuropharmacol. 2015 Jan; 13(1): 71–88. Juan Mielgo-Ayuso, Diego Marques-Jiménez, Ignacio Refoyo, Juan Del Coso, Patxi León-Guereño, and Julio 
5. Calleja-González. Effect of Caffeine Supplementation on Sports Performance Based on Differences Between Sexes: A Systematic Review. Nutrients. 2019 Oct; 11(10): 2313.
6. M Doherty , P M Smith. Effects of caffeine ingestion on rating of perceived exertion during and after exercise: a meta-analysis. Scand J Med Sci Sports. 2005 Apr;15(2):69-78.
7. Daniel T. Fuller, Matthew Lee Smith, and Ali Boolani. Trait Energy and Fatigue Modify the Effects of Caffeine on Mood, Cognitive and Fine-Motor Task Performance: A Post-Hoc Study. Nutrients. 2021 Feb; 13(2): 412.
8. P Koot , P Deurenberg. Comparison of changes in energy expenditure and body temperatures after caffeine consumption. Ann Nutr Metab. 1995;39(3):135-42. 
9. Christopher J Derry 1, Sheena Derry, R Andrew Moore. Caffeine as an analgesic adjuvant for acute pain in adults. Cochrane Database Syst Rev. . 2014 Dec 11;2014(12):CD009281.
10. Robert E Shapiro. Caffeine and headaches. Curr Pain Headache Rep. 2008 Aug;12(4):311-5. 
11. Laura M Juliano, Roland R Griffiths. A critical review of caffeine withdrawal: empirical validation of symptoms and signs, incidence, severity, and associated features. Psychopharmacology. 2004 Oct;176(1):1-29. 
12. Regina Wierzejska. Caffeine–common ingredient in a diet and its influence on human health. Rocz Panstw Zakl Hig. 2012;63(2):141-7.
13. Lisa Klevebrant , Andreas Frick. Effects of caffeine on anxiety and panic attacks in patients with panic disorder: A systematic review and meta-analysis. Gen Hosp Psychiatry. 2022 Jan-Feb:74:22-31.
14. W Koller, S Cone, G Herbster. Caffeine and tremor. Neurology. 1987 Jan;37(1):169-72.
15. Alexander Muacevic and John R Adler. Maternal Caffeine Consumption and Its Impact on the Fetus: A Review. Cureus. 2023 Nov; 15(11): e48266.
16. Christina Dietz , Matthijs Dekker. Effect of Green Tea Phytochemicals on Mood and Cognition. Curr Pharm Des. 2017;23(19):2876-2905. 
17. Anna C Nobre , Anling Rao, Gail N Owen. L-theanine, a natural constituent in tea, and its effect on mental state. Asia Pac J Clin Nutr. 2008:17 Suppl 1:167-8.
18. Muhammed Furkan Dasdelen , et. al. A Novel Theanine Complex, Mg-L-Theanine Improves Sleep Quality via Regulating Brain Electrochemical Activity. Front Nutr. 2022 Apr 5:9:874254. 
19. Takami Kakuda. Neuroprotective effects of theanine and its preventive effects on cognitive dysfunction. Pharmacol Res. 2011 Aug;64(2):162-8. 
20. Pradeep J Nathan , Kristy Lu, M Gray, C Oliver. The neuropharmacology of L-theanine(N-ethyl-L-glutamine): a possible neuroprotective and cognitive enhancing agent. J Herb Pharmacother. 2006;6(2):21-30.
21. Shinsuke Hidese, Shintaro Ogawa, Miho Ota, Ikki Ishida, Zenta Yasukawa, Makoto Ozeki, and Hiroshi Kunugi. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients. 2019 Oct; 11(10): 2362.
22. Gail N Owen, Holly Parnell, Eveline A De Bruin, Jane A Rycroft. The combined effects of L-theanine and caffeine on cognitive performance and mood. Nutr Neurosci. 2008 Aug;11(4):193-8.